The objective of the study was to assess the effect of 2,4-thiazolidinedione, a putative PPARgamma agonist, on the response to induced sub-clinical mastitis and milk fat production in lactating goats (project completed)
We determined that the daily injection of 8 mg/kg body weight of 2,4-thiazolidinedione improved the liver situation, the killing capacity of neutrophils, and decreased somatic cells in milk but did not affect the production of milk fat and the expression of any PPARgamma target gene in adipose tissue or mammary tissue. It is possible that the lack of the activation of PPARgamma was due to a less than optimal nutritional status of the goats.
2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis. Rosa F, Osorio JS, Trevisi E, Yanqui-Rivera F, Estill CT, Bionaz M. PPAR Res. 2017;2017:70974
Rosa F. T., Osorio J. S., Rivera F. Y., Trevisi E., Estill C. T., and M Bionaz. 2015. 2,4-thiazolidinedione improves liver function but does not affect insulin sensitivity and expression of genes in adipose and mammary tissue of lactating dairy goats. J. Anim. Sci Vol. 93, E-Suppl. 2/J. Dairy Sci. Vol. 98, E-Suppl. 1
Richards S. G., Robertson L., Dahl D., Johnston L., Estill C. T., and M Bionaz. 2014. Effect of 2,4-thiazolidinedione treatment in milk production and leukocytes phagocytosis after sub-clinical mastitis induction in lactating dairy goats. J. Dairy Sci. 97(E-Suppl. 1):419-420
Hatch/Multistate USDA Animal Health and Disease Grant no. NE1048 received by Massimo Bionaz and Charles T. Estill from the Oregon State University research station